|
KMID : 0371219970180000325
|
|
Medical Bulletin of the Presbyterian Medical Center
1997 Volume.18 No. 0 p.325 ~ p.335
|
|
|
IN VITRO STEM CELL SUPPRESSION OF MACROPHAGE INFLAMMATORY PROTEIN-1α
|
|
|
|
|
Abstract
|
|
|
The pro feratm of bone nw mw stem cell cornm nrent. is thot>& to be urOw both positive anid negative cm, trolls by cytolam arrd C*W starxialatug faders, MauWhW iraflarnmataY p dem la(MIP-la) has been assessed
I
far itss potesatW to prated hematopoietic seem Cells from cytotooac effects of a. cyile-speafic antiryeopdastic agents. We have tested the abifity of MIP-la to supPM the Pcmtiferation of stem cell Em Du. M 101 in variety of active status by using [´Hftrnidim inoaporatian test.
The malts were as follows.
1. the effect of MP-la on steady-state Du 528.101 oils represented the Cell growth ammion at the omoentra
av, vv, awsa.. w a.aaa eras\a ~wva/
2 NAP-la stnnuiated the prt feration of Da 528.101 cells p wiaxsly treated with 1G-1 at the concentration of 5, 50nM of M P-la(P3 mr suppression effect of MIP-1 on Du. 528.101 cells at the conoenua ion of 5, 50nM was shows when cells
were treated with MIP-la before activating with IG-1r8(P4. Ihe growth rate of symdunrvaed cells were slower than #hat of non-symdrau- ed ores, and MIIP-1a represented the samI r suppression effect on bath synd= iced and non-sync muted oche
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|